Levamisole HCl 3% & Oxyclozanide 6% Oral Suspension
FOR VETERINARY USE ONLY
COMPOSITION
Active ingredient: Levamisole Hydrochloride, 30mg/ml, w/v; Oxyclozanide, 60mg/ml,w/v.
Excipients: Sodium Benzoate, Carboxymethylcellulose Sodium, Purified Water.
DESCRIPTION
Suspension for oral.
A yellowish uniform suspension.
PHARMACOLOGICAL ACTIONS
Levamisole is an imidazothiazole that acts by interfering with parasite nerve transmission causing muscular paralysis. It is effective against adult and immature gastrointestinal roundworm and lungworm infections.
Oxyclozanide is a salicylanilide, which is mainly active against adult liver flukes. It is distributed to the liver, kidney and intestines and is excreted in the bile.
TARGET SPECIES
Cattle, calves, sheep and goats.
INDICATIONS
For the treatment and control of both gastrointestinal and pulmonary nematode infections, and adult liver fluke infections. Removes most mature Fasciola spp (flukes) present in the bile ducts of the liver.
ADMINISTRATION AND DOSAGE
For oral administration:
Cattle, calves: 2.5 ml per 10 kg body weight.
Sheep and goats: 1 ml per 4 kg body weight.
Shake well before use.
CONTRAINDICATIONS
Animals must not be treated within a period of 14 days before or after treatment with organophosphorus compounds.
PRECAUTIONS
Special precautions for use in animals
Care should be taken to estimate accurately the liveweight of animals to be treated. It is important that the container is shaken before use. After treatment, animals should be moved to clean pasture in order to prevent re-infection. Veterinary advice should be sought on appropriate dosing programmes to reduce the likelihood of anthelmintic resistance developing. Veterinary advice should be sought if the product does not achieve the desired clinical effect since other diseases, nutritional disturbances or anthelmintic resistance may be involved.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
Wash hands after use.
Keep out of the reach of children.
SPECIAL WARNINGS FOR EACH TARGET SPECIES
Care should be taken to avoid the following practices because they increase the risk of development of resistance and could ultimately result in ineffective therapy:
Too frequent and repeated use of anthelmintics from the same class, over an extended period of time.
Underdosing, which may be due to underestimation of body weight, misadministration of the product, or lack of calibration of the dosing device (if any).
ADVERSE REACTIONS
At normal oxyclozanide dose levels, cattle may show slight softening of the faeces with the occasional animal showing increased frequency of defecation and transient inappetence. Rarely, sheep may show an anaphylactic reaction with swelling of the head.
DRUG INTERACTIONS
Cattle must not be treated within a period of 14 days before or after treatment with organophosphorus compounds.
WITHDRAWAL PERIOD
For meat: 5 days.
For milk: Do not use in cattle and sheep producing milk for human consumption.
STORAGE
Sealed and store below 30°C. Protect from light.
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